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著者: J D Miller, R W Shaw, R F Casper, J A Rock, E J Thomas, W P Dmowski, E Surrey, L R Malinak, K Moghissi
雑誌名: Fertil Steril. 1998 Aug;70(2):293-6.
Abstract/Text
OBJECTIVE: To determine the duration of time to the recurrence of pain attributable to endometriosis after the discontinuation of treatment with danazol or a GnRH agonist (GnRH-a) in patients who have had a satisfactory response to the treatment.
DESIGN: Retrospective study.
SETTING: Nine academic medical centers in three countries.
PATIENT(S): Three hundred twenty-seven women with diagnosed and staged endometriosis who were treated with at least 6 months of danazol or a GnRH-a and who experienced significant pain relief with therapy.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Duration of pain relief after completion of treatment as determined by a patient-initiated report of pain recurrence or increase in pain severity requiring intervention.
RESULT(S): The median time to the recurrence of pain was 6.1 months for patients treated with danazol and 5.2 months for patients treated with a GnRH-a.
CONCLUSION(S): Although there was a lack of uniformity in treatment effects across sites, the analyses have taken into account major covariant effects. The time to the recurrence of endometriosis-associated pain after danazol treatment was slightly longer than that after GnRH-a treatment.
PMID 9696224 Fertil Steril. 1998 Aug;70(2):293-6.
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