| |
著者: Hye Jin Chang, Sang Hoon Han, Jung Ryeol Lee, Byung Chul Jee, Byoung Ick Lee, Chang Suk Suh, Seok Hyun Kim
雑誌名: Fertil Steril. 2010 Jun;94(1):343-9. doi: 10.1016/j.fertnstert.2009.02.022. Epub 2009 Apr 5.
Abstract/Text
OBJECTIVE: To evaluate the ovarian reserve changes after laparoscopic cystectomy, we prospectively evaluated pre- and postoperative serum anti-Müllerian hormone (AMH) level, and ovarian volumes.
DESIGN: Prospective longitudinal study.
SETTING: University Hospital.
PATIENT(S): Twenty women with benign ovarian masses participated; endometrioma [13], mature teratoma [6], and mucinous cystadenoma [1]. Seven patients had bilateral ovarian masses.
INTERVENTION(S): All patients had undergone laparoscopic ovarian cystectomy. Serum AMH levels were serially measured: preoperative, 1 week, 1 month, and 3 months after operation. Volumes of total ovary and ovarian mass were measured by 3D ultrasonography before operation.
MAIN OUTCOME MEASURE(S): Postoperative serum AMH level and ovarian volume.
RESULT(S): Median AMH level was 2.23 ng/mL (95% confidence interval [CI] 1.35-3.41 ng/mL) before operation, but reduced to 0.67 ng/mL (95% CI 0.44-1.70 ng/mL) at the first week postoperatively and then increased to 1.14 ng/mL (95% CI 0.79-2.36 ng/mL) in the first month and 1.50 ng/mL (95% CI 0.58-3.26 ng/mL) in the third month. The serum AMH level after 3 months postoperatively was recovered to about 65% of the preoperative level. The serum AMH level at postoperative 1 week was more decreased in endometrioma compared with nonendometrioma (33.9% vs. 69.2% of preoperative level), and in bilateral group compared with unilateral group (16.9% vs. 62.9%).
CONCLUSION(S): This study suggests that ovarian reserve could be reduced after laparoscopic cystectomy; however, it could be restored thereafter up to 3 months postoperative in reproductive women.
Copyright (c) 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
PMID 19345350 Fertil Steril. 2010 Jun;94(1):343-9. doi: 10.1016/j.fertnstert.2009.02.022. Epub 2009 Apr 5.
|
