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著者: Byung Chul Jee, Joong Yeup Lee, Chang Suk Suh, Seok Hyun Kim, Young Min Choi, Shin Yong Moon
雑誌名: Fertil Steril. 2009 Jan;91(1):40-5. doi: 10.1016/j.fertnstert.2007.11.027. Epub 2008 Apr 18.
Abstract/Text
OBJECTIVE: To analyze the influence of postoperative GnRH agonist treatment on disease recurrence after conservative laparoscopic surgery for ovarian endometriomas according to duration of the treatment.
DESIGN: Retrospective cohort study.
SETTING: University hospital.
PATIENT(S): One hundred nine consecutive premenopausal women who underwent conservative laparoscopic surgery for ovarian endometriomas (endometriosis stage III/IV) were enrolled in the study. The patients were divided into four treatment groups: expectant management (n = 37) and GnRH agonist therapy for 3 (n = 28), 4 (n = 21), and 6 months (n = 23).
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): An ultrasound confirmed recurrence of ovarian endometriomas.
RESULT(S): The overall crude recurrence rate was 16.5% after follow-up for an average of 20.1 months. The crude recurrence and the cumulative probabilities of disease recurrence at 24/36 months tended to be lower in patients who received a GnRH agonist for 6 months (4.3%, 5.3%/5.3%) compared with those who received it for 3 months (17.9%, 12.5%/25.0%) and 4 months (28.6%, 18.9%/39.2%) and patients with expectant management (16.2%, 22.4%/37.9%). However, the differences did not reach statistical significance.
CONCLUSION(S): Treatment with GnRH agonist for six months had a beneficial impact on the recurrence rate after conservative laparoscopic surgery for ovarian endometriomas.
PMID 18377899 Fertil Steril. 2009 Jan;91(1):40-5. doi: 10.1016/j.fertnstert.2007.11.027. Epub 2008 Apr 18.
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