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著者: Per Brandström, Elisabeth Esbjörner, Maria Herthelius, Gundela Holmdahl, Göran Läckgren, Tryggve Nevéus, Ulla Sillén, Rune Sixt, Ingrid Sjöberg, Eira Stokland, Ulf Jodal, Sverker Hansson
雑誌名: J Urol. 2010 Jul;184(1):274-9. doi: 10.1016/j.juro.2010.01.055. Epub 2010 May 15.
Abstract/Text
PURPOSE: We compared the rates of febrile urinary tract infection, kidney damage and reflux resolution in children with vesicoureteral reflux treated in 3 ways, including antibiotic prophylaxis, endoscopic therapy and surveillance with antibiotics only for symptomatic urinary tract infection.
MATERIALS AND METHODS: Children 1 to younger than 2 years with grade III-IV reflux were recruited into this prospective, open, randomized, controlled, multicenter study and followed for 2 years after randomization. The main study end points were recurrent febrile urinary tract infection, renal status on dimercapto-succinic acid scintigraphy and reflux status. Outcomes were analyzed by the intent to treat principle.
RESULTS: During a 6-year period 128 girls and 75 boys entered the study. In 96% of cases reflux was detected after urinary tract infection. The randomization procedure was successful and resulted in 3 groups matched for relevant factors. Recruitment was slower than anticipated but after patients were entered adherence to the protocol was good. Of the children 93% were followed for the intended 2 years without a treatment arm change. All except 2 patients completed 2-year followup scintigraphy.
CONCLUSIONS: Recruitment was difficult but a substantial number of children were entered and randomly assigned to 3 groups with similar basic characteristics. Good adherence to the protocol made it possible to address the central study questions.
Copyright (c) 2010 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.
PMID 20478580 J Urol. 2010 Jul;184(1):274-9. doi: 10.1016/j.juro.2010.01.055. Epub 2010 May 15.
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