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著者: Kenji Hirano, Minoru Tada, Hiroyuki Isayama, Keisuke Yamamoto, Suguru Mizuno, Hiroshi Yagioka, Yoko Yashima, Takashi Sasaki, Hirofumi Kogure, Osamu Togawa, Toshihiko Arizumi, Saburo Matsubara, Yousuke Nakai, Naoki Sasahira, Takeshi Tsujino, Takao Kawabe, Masao Omata
雑誌名: Gastrointest Endosc. 2010 Jan;71(1):85-90. doi: 10.1016/j.gie.2009.08.008.
Abstract/Text
BACKGROUND: Intrapancreatic bile duct stricture in autoimmune pancreatitis (AIP) is usually diagnosed as sclerosing cholangitis even if the stricture is limited to the intrapancreatic area. However, it is not known whether compression caused by pancreatic edema or biliary wall thickening causes such a biliary stricture.
OBJECTIVE: Our purpose was to clarify the factor that contributes to intrapancreatic biliary stricture in AIP: pancreatic head lesion or biliary wall thickening.
DESIGN: Single-center retrospective study.
SETTING: This study was performed in a tertiary care academic medical center.
PATIENTS: Fifty-six patients with AIP were included.
MAIN OUTCOME MEASUREMENTS: The relationship between the presence of a pancreatic head lesion and intrapancreatic biliary stricture was examined. In addition, the relationship between the extent of the intrapancreatic biliary stricture and the wall thickening was evaluated.
RESULTS: Among 44 patients with a pancreatic head lesion, 41 (93%) had intrapancreatic bile duct stricture. Among 12 patients without a pancreatic head lesion, only 2 had such a stricture (P < .0001). Intraductal US showed average intrapancreatic biliary wall thickening with severe stricture of 2.7 +/- 1.0 mm, significantly thicker than that with mild stricture (1.9 +/- 0.35 mm; P = .0200).
LIMITATIONS: Intraductal US was not performed in all patients.
CONCLUSIONS: Both pancreatic edema and biliary wall thickening influenced intrapancreatic biliary stricture in AIP. This type of stricture should be differentiated from extrapancreatic biliary stricture that may be caused by biliary wall thickening only.
2010 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.
PMID 19836737 Gastrointest Endosc. 2010 Jan;71(1):85-90. doi: 10.1016/j.gie.2009.08.008.
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