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		7:	Efficacy of vitamin B-6 in the treatment of premenstrual syndrome: systematic review.
			著者: Wyatt KM, Dimmock PW, Jones PW, Shaughn O'Brien PM. 雑誌名: BMJ. 1999 May 22;318(7195):1375-81. doi: 10.1136/bmj.318.7195.1375. Abstract/Text OBJECTIVE: To evaluate the efficacy of vitamin B-6 in the treatment of premenstrual syndrome. DESIGN: Systematic review of published and unpublished randomised placebo controlled trials of the effectiveness of vitamin B-6 in the management of premenstrual syndrome. SUBJECTS: Nine published trials representing 940 patients with premenstrual syndrome. MAIN OUTCOME MEASURES: Proportion of women whose overall premenstrual symptoms showed an improvement over placebo. A secondary analysis was performed on the proportion of women whose premenstrual depressive symptoms showed an improvement over placebo. RESULTS: Odds ratio relative to placebo for an improvement in overall premenstrual symptoms was 2.32 (95% confidence interval 1.95 to 2.54). Odds ratio relative to placebo for an improvement in depressive symptoms was 1.69 (1.39 to 2.06) from four trials representing 541 patients. CONCLUSION: Conclusions are limited by the low quality of most of the trials included. Results suggest that doses of vitamin B-6 up to 100 mg/day are likely to be of benefit in treating premenstrual symptoms and premenstrual depression. PMID 10334745 BMJ. 1999 May 22;318(7195):1375-81. doi: 10.1136/bmj.318.7195.1375.