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著者: Hiroyuki Yamamoto, Toru Hashimoto, Keiko Ohta-Ogo, Hatuse Ishibashi-Ueda, Kyoko Imanaka-Yoshida, Michiaki Hiroe, Tomoki Yokochi
雑誌名: Cardiovasc Pathol. 2018 Nov - Dec;37:54-57. doi: 10.1016/j.carpath.2018.10.003. Epub 2018 Oct 9.
Abstract/Text
Vaccine-associated myocarditis is an extremely rare, yet potentially lethal disease, which requires early diagnosis and prompt treatment. However, its pathogenesis remains elusive. We report the first case of biopsy-proven eosinophilic myocarditis related to tetanus toxoid immunization, with unique histopathologic findings, characterized by perivascular eosinophilic infiltrates with myocyte necrosis and abundant interstitial lymphocytic infiltrates with myocyte necrosis, separately. A systemic high-dose corticosteroid treatment had a dramatic beneficial effect on hemodynamic instability and resulted in complete recovery. This case highlights the value of endomyocardial biopsy in establishing a definite diagnosis and understanding the pathogenesis of vaccine-associated myocarditis.
Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.
PMID 30343188 Cardiovasc Pathol. 2018 Nov - Dec;37:54-57. doi: 10.1016/j.carpath.2018.10.003. Epub 2018 Oct 9.
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