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著者: P M Mannucci, G Tamaro, G Narchi, G Candotti, A Federici, D Altieri, F Tedesco
雑誌名: Eur J Haematol. 1987 Nov;39(5):467-70.
Abstract/Text
A 16-yr-old girl with severe von Willebrand disease complicated by the development of precipitating alloantibodies to von Willebrand factor (anti-VWF) had a life-threatening anaphylactoid reaction immediately after the infusion of a commercial plasma concentrate of factor VIII/von Willebrand factor. An early post-infusion activation of the complement system was demonstrated by the appearance of C3 split products and by the drop of serum CH50 activity, occurring in parallel with a post-infusion drop in the anti-VWF antibody levels. Immune complexes remained unchanged in the early post-infusion period and rose to a moderate extent only after 24 h. We conclude that biologically active products of the complement system contributed to the onset of this life-threatening reaction which occurred after concentrate infusion.
PMID 3121382 Eur J Haematol. 1987 Nov;39(5):467-70.
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