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著者: M Paciaroni, D Georgiadis, M Arnold, J Gandjour, B Keseru, G Fahrni, V Caso, R W Baumgartner
雑誌名: J Neurol Neurosurg Psychiatry. 2006 May;77(5):677-9. doi: 10.1136/jnnp.2005.077073.
Abstract/Text
We examined the seasonal variability of spontaneous cervical artery dissection (sCAD) by analysing prospectively collected data from 352 patients with 380 sCAD (361 symptomatic sCAD; 305 carotid and 75 vertebral artery dissections) admitted to two university hospitals with a catchment area of 2,200,000 inhabitants between 1985 and 2004. Presenting symptoms and signs of the 380 sCAD were ischaemic stroke in 241 (63%), transient ischaemic attack in 40 (11%), retinal ischemia in seven (2%), and non-ischaemic in 73 (19%) cases; 19 (5%) were asymptomatic sCAD. A seasonal pattern, with higher frequency of sCAD in winter (31.3%; 95% confidence interval (CI): 26.5 to 36.4; p=0.021) compared to spring (25.5%; 95% CI: 21.1 to 30.3), summer (23.5%; 95% CI: 19.3 to 28.3), and autumn (19.7%; 95% CI: 15.7 to 24.1) was observed. Although the cause of seasonality in sCAD is unclear, the winter peaks of infection, hypertension, and aortic dissection suggest common underlying mechanisms.
PMID 16614034 J Neurol Neurosurg Psychiatry. 2006 May;77(5):677-9. doi: 10.1136/jnnp.2005.077073.
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