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著者: H S Zackheim, M Kashani-Sabet, S T Hwang
雑誌名: J Am Acad Dermatol. 1996 Apr;34(4):626-31.
Abstract/Text
BACKGROUND: Most patients with erythrodermic cutaneous T-cell lymphoma (CTCL) have intense, generalized, refractory pruritus. In some large series the median survival was approximately 3 years.
OBJECTIVE: Our purpose was to review our experience with methotrexate in the treatment of 29 patients with erythrodermic CTCL observed for up to 129 months.
METHODS: This is a retrospective study. Data are presented in terms of response rates, freedom from treatment failure, and overall survival.
RESULTS: Twelve patients (41%) achieved complete remission, and five (17%) achieved partial remission for a total response rate of 58%. The median freedom from treatment failure was 31 months, and the median survival was 8.4 years. Side effects caused treatment failure in only two patients.
CONCLUSION: Low-dose methotrexate is a valuable first-line treatment for the majority of patients with early to intermediate-stage erythordermic CTCL.
PMID 8601652 J Am Acad Dermatol. 1996 Apr;34(4):626-31.
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