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著者: Achuyt Bhattarai, Julie Villanueva, Rakhee S Palekar, Ryan Fagan, Wendy Sessions, Jörn Winter, Lashondra Berman, James Lute, Rebecca Leap, Tiffany Marchbanks, Samir V Sodha, Mària Moll, Xiyan Xu, Alicia Fry, Anthony Fiore, Stephen Ostroff, David L Swerdlow, Pennsylvania Working Group
雑誌名: Clin Infect Dis. 2011 Jan 1;52 Suppl 1:S102-8. doi: 10.1093/cid/ciq026.
Abstract/Text
We report shedding duration of 2009 pandemic influenza A (pH1N1) virus from a school-associated outbreak in Pennsylvania during May through June 2009. Outbreak-associated students or household contacts with influenza-like illness (ILI) onset within 7 days of interview were recruited. Nasopharyngeal specimens, collected every 48 hours until 2 consecutive nonpositive tests, underwent real-time reverse transcriptase polymerase chain reaction (rRT-PCR) and culture for pH1N1 virus. Culture-positive specimens underwent virus titrations. Twenty-six (median age, 8 years) rRT-PCR-positive persons, for pH1N1 virus, were included in analysis. Median shedding duration from fever onset by rRT-PCR was 6 days (range, 1-13) and 5 days (range, 1-7) by culture. Following fever resolution virus was isolated for a median of 2 days (range, 0-5). Highest and lowest virus titers detected, 2 and 5 days following fever onset, were 3.2 and 1.2 log(10) TCID(50)/mL respectively. Overall, shedding duration in children and adults were similar to seasonal influenza viruses.
PMID 21342880 Clin Infect Dis. 2011 Jan 1;52 Suppl 1:S102-8. doi: 10.1093/cid/ciq026.
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