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著者: Chiung-Zuan Chiu, Satoshi Nakatani, Guican Zhang, Teruo Tachibana, Fumio Ohmori, Masakazu Yamagishi, Masafumi Kitakaze, Hitonobu Tomoike, Kunio Miyatake
雑誌名: Am J Cardiol. 2005 Jan 1;95(1):143-6. doi: 10.1016/j.amjcard.2004.08.083.
Abstract/Text
Forty-three patients with cardiac sarcoidosis were studied echocardiographically before and after (mean follow-up 88 months) steroid therapy to determine the effectiveness of corticosteroids to prevent left ventricular (LV) remodeling and improve LV contractility. In patients with initial LV ejection fractions (LVEFs) >or=55%, long-term steroid therapy showed preventive effects for LV remodeling and LV function. Patients with LVEF <54% showed significant reductions of LV volumes and LVEF improvement. However, in patients with LVEFs <30%, steroid therapy resulted in neither LV volume reductions nor improved LVEFs. In the early or middle stage of the disease, steroid therapy may be protective or therapeutic in preventing LV remodeling and preserving LV function. However, it may not be as effective in the late stage.
PMID 15619415 Am J Cardiol. 2005 Jan 1;95(1):143-6. doi: 10.1016/j.amjcard.2004.08.083.
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