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著者: Takashi Araki, Hiroto Ishikawa, Chiharu Iwahashi, Masanori Niki, Yoshinori Mitamura, Masahiko Sugimoto, Mineo Kondo, Takamasa Kinoshita, Tomo Nishi, Tetsuo Ueda, Aki Kato, Tsutomu Yasukawa, Yoshihiro Takamura, Fumi Gomi
雑誌名: PLoS One. 2019;14(2):e0213110. doi: 10.1371/journal.pone.0213110. Epub 2019 Feb 28.
Abstract/Text
We investigated the rates of the use of steroids in Japanese central serous chorioretinopathy (CSC) cases and differences in the characteristics of CSC with and without steroids. A total of 538 eyes of 477 patients diagnosed with CSC, with 3 months or more of follow-up between April 2013 and June 2017 at 8 institutions. Patients with CSC with more than 3 months of follow-up were identified by OCT and fluorescein angiography at 8 institutions. Data collected included patient demographics, history of corticosteroid medication and smoking, spherical errors, findings of angiography, subfoveal choroidal thickness, and changes through the follow-up period. Differences in these findings were analyzed in cases with and without corticosteroid treatment. Among the 477 patients (344 men,133 women), 74 (15.5%) (39 men, 35 women) underwent current or prior steroid treatment. Cases with steroids were higher age (p = 0.0403) and showed no male prevalence, more bilateral involvement (p < 0.0001), and the affected eyes had multiple pigment epithelial detachment (p <0.0001), more fluorescein leakage sites (p < 0.0001), greater choroidal thickness (p = 0.0287) and a higher recurrence rate (p = 0.0412). Steroids can cause severer CSC through an effect on choroidal vessels and an impairment of retinal pigment epithelium.
PMID 30818363 PLoS One. 2019;14(2):e0213110. doi: 10.1371/journal.pone.0213110. Epub 2019 Feb 28.
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