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著者: Cynthia A Carvalho-Recchia, Lawrence A Yannuzzi, Silvana Negrão, Richard F Spaide, K Bailey Freund, Hanna Rodriguez-Coleman, Marcio Lenharo, Tomohiro Iida
雑誌名: Ophthalmology. 2002 Oct;109(10):1834-7.
Abstract/Text
PURPOSE: The purpose of this study is to investigate the relationship between corticosteroid use and central serous chorioretinopathy (CSC).
DESIGN: A prospective, case-controlled study.
PARTICIPANTS AND CONTROLS: A consecutive series of patients with acute manifestations of CSC and a control group matched for age, race, and gender were recruited between January 2000 and July 2000.
METHODS: A detailed clinical history was taken, and fundus examination with slit-lamp biomicroscopy was performed on all patients. Fluorescein angiography was obtained on the study patients.
RESULTS: A total of 50 patients was recruited. Twenty-six patients (52%) had a history of exogenous steroid use, including oral, intravenous, intranasal, and intraarticular administration. Two additional patients had a history of endogenous hypercortisolism (Cushing's syndrome). In a matched control group, eight patients (18%) had a history of steroid use. The difference in corticosteroid exposure between study patients and controls was statistically significant (P < 0.0001).
MAIN OUTCOME MEASURES: History of corticosteroid use or Cushing's syndrome.
CONCLUSIONS: This study is consistent with previous reports associating steroid use with CSC. It identifies corticosteroids as a significant risk factor for the development of acute, exudative macular manifestation and implicates hypercortisolism as a factor in the pathogenesis of this disorder. Several forms of corticosteroid administration were observed to be a risk factor for CSC. Accordingly, susceptible patients in need of corticosteroids should be advised of the risk of developing acute manifestations of CSC.
PMID 12359603 Ophthalmology. 2002 Oct;109(10):1834-7.
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