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著者: L W Hirst, A W Clark, J S Wolinsky, D S Zee, H Kaizer, N R Miller, P J Tutschka, G W Santos
雑誌名: J Clin Neuroophthalmol. 1983 Dec;3(4):245-9.
Abstract/Text
A 35-year-old man with aplastic anemia developed prominent downbeat nystagmus 80 days after receiving an allogeneic bone marrow transplant. A diagnosis of herpes simplex encephalitis was made which was confirmed by positive virus cultures at autopsy 1 week later. Routine pathologic examination of the brain stem revealed no lesions which would explain the downbeat nystagmus. Immunoperoxidase studies, however, revealed virus-infected neurones throughout the brain stem including the nuclei of the basis pontis, the superior olive, and nuclei of the spinal tracts of 5 and 10. The significance of "negative" pathologic brain stem findings in cases of downbeat nystagmus is discussed.
PMID 6232289 J Clin Neuroophthalmol. 1983 Dec;3(4):245-9.
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