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著者: Nakao YK, Motomura M, Fukudome T, Fukuda T, Shiraishi H, Yoshimura T, Tsujihata M, Eguchi K.
雑誌名: Neurology. 2002 Dec 10;59(11):1773-5. doi: 10.1212/01.wnl.0000037485.56217.5f.
Abstract/Text
The authors characterized the clinical and immunologic features of 110 patients with Lambert-Eaton myasthenic syndrome (LEMS). Anti-P/Q-type voltage-gated calcium channels (VGCC) antibodies were detected in 85% of the patients (seropositive) but not in the rest (seronegative). Except for the indication that small cell lung carcinoma is less common in seronegative patients, no significant differences were found in the clinical characteristics of patients who had or did not have anti-P/Q-type VGCC antibodies. The results of passive transfer experiments suggest that seronegative LEMS is also an autoantibody-mediated disorder.
PMID 12473768 Neurology. 2002 Dec 10;59(11):1773-5. doi: 10.1212/01.wnl.0000037485.56217.5f.
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