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著者: K H Nicolaides, G Azar, D Byrne, C Mansur, K Marks
雑誌名: BMJ. 1992 Apr 4;304(6831):867-9.
Abstract/Text
OBJECTIVE: To examine the significance of fetal nuchal translucency at 10-14 weeks' gestation in the prediction of abnormal fetal karyotype.
DESIGN: Prospective screening study.
SETTING: The Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London.
SUBJECTS: 827 fetuses undergoing first trimester karyotyping by amniocentesis or chorionic villus sampling.
MAIN OUTCOME MEASURE: Incidence of chromosomal defects.
RESULTS: The incidence of chromosomal defects was 3% (28 of 827 cases). In the 51 (6%) fetuses with nuchal translucency 3-8 mm thick the incidence of chromosomal defects was 35% (18 cases). In contrast, only 10 of the remaining 776 (1%) fetuses were chromosomally abnormal.
CONCLUSION: Fetal nuchal translucency > or = 3 mm is a useful first trimester marker for fetal chromosomal abnormalities.
PMID 1392745 BMJ. 1992 Apr 4;304(6831):867-9.
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