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著者: Yiannakis EP, Boswell TC.
雑誌名: J Hosp Infect. 2016 May;93(1):1-8. doi: 10.1016/j.jhin.2016.01.018. Epub 2016 Feb 10.
Abstract/Text
BACKGROUND: Pneumocystis jirovecii pneumonia (PCP) is an important cause of morbidity and mortality in immunocompromised patients. Several nosocomial outbreaks of PCP have been reported in human-immunodeficiency-virus-negative, immunocompromised patients. The primary route of P. jirovecii transmission has yet to be proven; however, these outbreaks of infection suggest either interhuman transmission or a common environmental source.
AIM: To identify and evaluate all published clusters and outbreaks of PCP. The main objective was to compare the epidemiology of the outbreaks, with a particular focus on the evidence for different modes of transmission.
METHODS: PubMed and EMBASE were searched to identify all English-language articles describing PCP outbreaks or clusters between 1980 and March 2015. Data were extracted on the outbreak setting, features of the outbreak, application of molecular typing, results of epidemiological assessment and environmental sampling.
FINDINGS: Thirty outbreaks described in 29 articles were identified. Twenty-five (83%) of these outbreaks were described in patients who had undergone solid organ transplantation, primarily renal transplantation. All studies described a defined cohort of patients who shared some nosocomial facilities, including both inpatient and outpatient areas. Genotyping was undertaken in 16 (47%) studies. Cases with an identical genotype were demonstrated in all these studies.
CONCLUSIONS: The findings of this review raise a number of concerns regarding the public health and infection control implications of infection with PCP. The evidence presented for nosocomial acquisition and possible person-to-person transmission of infection suggests the need for formal infection control policies.
Copyright © 2016 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
PMID 26996089 J Hosp Infect. 2016 May;93(1):1-8. doi: 10.1016/j.jhin.2016.01.018. Epub 2016 Feb 10.
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