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著者: Craig R Walsh, Martin G Larson, Jane C Evans, Luc Djousse, R Curtis Ellison, Ramachandran S Vasan, Daniel Levy
雑誌名: Ann Intern Med. 2002 Feb 5;136(3):181-91.
Abstract/Text
BACKGROUND: Although excessive alcohol consumption can promote cardiomyopathy, little is known about the association between alcohol consumption and risk for congestive heart failure in the community.
OBJECTIVE: To determine the relation between alcohol consumption and risk for congestive heart failure in the community.
DESIGN: Community-based, prospective observational study.
SETTING: Framingham, Massachusetts.
PARTICIPANTS: Participants in the Framingham Heart Study who were free of congestive heart failure and coronary heart disease.
MEASUREMENTS: Self-reported alcohol consumption; sex-specific rates of congestive heart failure per 1000 person-years of follow-up by level of alcohol consumption.
RESULTS: In men, 99 cases of congestive heart failure occurred during 26 035 person-years of follow-up. In women, 120 cases of congestive heart failure occurred during 35 563 person-years of follow-up. After adjustment for multiple confounders, risk for congestive heart failure was lower among men at all levels of alcohol consumption compared with men who consumed less than 1 drink/wk. The hazard ratio for congestive heart failure was lowest among men who consumed 8 to 14 drinks/wk (0.41 [95% CI, 0.21 to 0.81]) compared with those who consumed less than 1 drink/wk. In women, the age-adjusted hazard ratio for congestive heart failure was lowest among those who consumed 3 to 7 drinks/wk (0.49 [CI, 0.25 to 0.96]) compared with those who consumed less than 1 drink/wk. However, after adjustment for multiple predictors of congestive heart failure, this association was no longer statistically significant.
CONCLUSIONS: In the community, alcohol consumption is not associated with increased risk for congestive heart failure, even among heavy drinkers (> or = 15 drinks/wk in men and > or = 8 drinks/wk in women). To the contrary, when consumed in moderation, alcohol appears to protect against congestive heart failure.
PMID 11827493 Ann Intern Med. 2002 Feb 5;136(3):181-91.
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