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著者: Edmund Sonuga-Barke, Paraskevi Bitsakou, Margaret Thompson
雑誌名: J Am Acad Child Adolesc Psychiatry. 2010 Apr;49(4):345-55. doi: 10.1016/j.jaac.2009.12.018.
Abstract/Text
OBJECTIVE: The dual pathway model explains neuro-psychological heterogeneity in Attention Deficit/Hyperactivity Disorder (ADHD) in terms of dissociable cognitive and motivational deficits each affecting some but not other patients. We explore whether deficits in temporal processing might constitute a third dissociable neuropsychological component of ADHD.
METHOD: Nine tasks designed to tap three domains (inhibitory control, delay aversion and temporal processing) were administered to ADHD probands (n=71; ages 6 to 17 years), their siblings (n=71; 65 unaffected by ADHD) and a group of non-ADHD controls (n=50). IQ and working memory were measured.
RESULTS: Temporal processing, inhibitory control and delay-related deficits represented independent neuropsychological components. ADHD children differed from controls on all factors. For ADHD patients, the co-occurrence of inhibitory, temporal processing and delay-related deficits was no greater than expected by chance with substantial groups of patients showing only one problem. Domain-specific patterns of familial co-segregation provided evidence for the validity of neuropsychological subgroupings.
CONCLUSION: The current results illustrate the neuropsychological heterogeneity in ADHD and initial support for a triple pathway model. The findings need to be replicated in larger samples.
PMID 20410727 J Am Acad Child Adolesc Psychiatry. 2010 Apr;49(4):345-55. doi: 10.1016/j.jaac.2009.12.018.
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