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著者: Sean J Colloby, John T O'Brien, John D Fenwick, Michael J Firbank, David J Burn, Ian G McKeith, E David Williams
雑誌名: Neuroimage. 2004 Nov;23(3):956-66. doi: 10.1016/j.neuroimage.2004.06.045.
Abstract/Text
Dopaminergic loss can be visualised using (123)I-FP-CIT single photon emission computed tomography (SPECT) in several disorders including Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Most previous SPECT studies have adopted region of interest (ROI) methods for analysis, which are subjective and operator-dependent. The purpose of this study was to investigate differences in striatal binding of (123)I-FP-CIT SPECT using the automated technique of statistical parametric mapping (SPM99) in subjects with DLB, Alzheimer's disease (AD), PD and healthy age-matched controls. This involved spatial normalisation of each subject's image to a customised template, followed by smoothing and intensity normalisation of each image to its corresponding mean occipital count per voxel. Group differences were assessed using a two-sample t test. Applying a height threshold of P
PMID 15528096 Neuroimage. 2004 Nov;23(3):956-66. doi: 10.1016/j.neuroimage.2004.06.045.
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