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著者: I N Shaw, M M Natrajan, G S Rao, K Jesudasan, M Christian, M Kavitha
雑誌名: Int J Lepr Other Mycobact Dis. 2000 Dec;68(4):405-9.
Abstract/Text
Forty-six, newly detected, previously untreated multibacillary (MB) patients with a bacterial index (BI) of > or = 3+ who had received WHO/MDT for 2 years were followed up for a total duration of 424 person-years and a mean duration of 9.26 +/- 2.98 years per patient. The BIs of the patients continued to fall, and all of the patients, except one, reached skin-smear negativity. WHO/MDT was well accepted and well tolerated. Relapse, which was defined as an increase in the BI of 1+ or more with or without clinical evidence of activity, was observed in only one patient, giving a relapse rate of 2.2% or 0.23 per 100 person-years in patients with a BI of > or = 3+ after long-term follow up. This patient was started on a second course of WHO/MDT to which he responded favorably. WHO/MDT for a fixed duration of 2 years for MB patients as recommended by the WHO is vindicated.
PMID 11332283 Int J Lepr Other Mycobact Dis. 2000 Dec;68(4):405-9.
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