著者: Yasushi Sato, Norio Yasui-Furukori, Sunao Kaneko, Takako Moriyama
雑誌名: Prog Neuropsychopharmacol Biol Psychiatry. 2008 Feb 15;32(2):577-8. doi: 10.1016/j.pnpbp.2007.08.039. Epub 2007 Sep 4.
Abstract/Text
PMID
17919798 Prog Neuropsychopharmacol Biol Psychiatry. 2008 Feb 15;･･･
著者: Satoshi Ninagawa, Seiichiro Tada, Masaki Okumura, Kenta Inoguchi, Misaki Kinoshita, Shingo Kanemura, Koshi Imami, Hajime Umezawa, Tokiro Ishikawa, Robert B Mackin, Seiji Torii, Yasushi Ishihama, Kenji Inaba, Takayuki Anazawa, Takahiko Nagamine, Kazutoshi Mori
雑誌名: Elife. 2020 Nov 17;9. doi: 10.7554/eLife.60970. Epub 2020 Nov 17.
Abstract/Text
Second-generation antipsychotics are widely used to medicate patients with schizophrenia, but may cause metabolic side effects such as diabetes, which has been considered to result from obesity-associated insulin resistance. Olanzapine is particularly well known for this effect. However, clinical studies have suggested that olanzapine-induced hyperglycemia in certain patients cannot be explained by such a generalized mechanism. Here, we focused on the effects of olanzapine on insulin biosynthesis and secretion by mouse insulinoma MIN6 cells. Olanzapine reduced maturation of proinsulin, and thereby inhibited secretion of insulin; and specifically shifted the primary localization of proinsulin from insulin granules to the endoplasmic reticulum. This was due to olanzapine's impairment of proper disulfide bond formation in proinsulin, although direct targets of olanzapine remain undetermined. Olanzapine-induced proinsulin misfolding and subsequent decrease also occurred at the mouse level. This mechanism of olanzapine-induced β-cell dysfunction should be considered, together with weight gain, when patients are administered olanzapine.
© 2020, Ninagawa et al.
PMID
33198886 Elife. 2020 Nov 17;9. doi: 10.7554/eLife.60970. Epub 20･･･
著者: E Kevin Heist, Jeremy N Ruskin
雑誌名: Circulation. 2010 Oct 5;122(14):1426-35. doi: 10.1161/CIRCULATIONAHA.109.894725.
Abstract/Text
PMID
20921449 Circulation. 2010 Oct 5;122(14):1426-35. doi: 10.1161/C･･･
著者: T Steinert, H Baier, W Fröscher, M Jandl
雑誌名: Fortschr Neurol Psychiatr. 2011 Mar;79(3):138-43. doi: 10.1055/s-0029-1245704. Epub 2010 Nov 23.
Abstract/Text
Epileptic seizures are observed during treatment with antidepressants and neuroleptics more frequently than is the case for other neuroactive substances. Evidence from experimental and observational studies is mixed, suggesting an increased incidence of seizures for certain drugs, whilst other drugs such as SSRIs appear to have a protective effect. There is robust evidence for an elevated seizure incidence (up to 4.5 % of treated patients) associated with clozapine treatment, but with other neuroleptics the effect is moderate (2-fold). The evaluation of data from FDA approval reports reveals lower standardised incidence rates associated with antidepressants vs. placebo except for clomipramine and bupropione. Psychiatric disorders such as schizophrenia, depression, and obsessive-compulsive disorder are associated with a considerably increased incidence of seizures. Therefore, in clinical practice, taking into account ictogenic properties of substances is required only in patients with a history of seizures.
© Georg Thieme Verlag KG Stuttgart · New York.
PMID
21104599 Fortschr Neurol Psychiatr. 2011 Mar;79(3):138-43. doi: ･･･
著者: Bo Westergaard, Lotte Christine Groth Hoegberg, Thor Buch Groenlykke
雑誌名: Clin Toxicol (Phila). 2012 Feb;50(2):129-35. doi: 10.3109/15563650.2011.650792. Epub 2012 Jan 31.
Abstract/Text
OBJECTIVE: Recent reviews strongly discourage the routine use of gastric lavage in oral poisonings, but the authors suspected that gastric lavage might still be in widespread use in Denmark. We wished to estimate the extent to which gastric lavage in cases of medical drug poisoning, reported in inquiries to the Danish Poison Information Centre (DPIC) from 2007 to 2010, was performed according to international recommendations and whether adherence to recommendations improved over the period.
METHODS AND MATERIALS: Inquiries from hospital and emergency departments (EDs) concerning medical drug poisonings were identified in the DPIC database. Patients receiving gastric lavage prior to inquiry were identified, and demographic and poisoning characteristics were retrieved. Indication for gastric lavage was determined from a predefined set of criteria.
RESULTS: 10 740 inquiries from hospitals and EDs were identified, of which 1091 cases received gastric lavage. In logistic regression, the frequency of lavage fell significantly from 13.5% in 2007 to 7.9% in 2010 (odds ratio (OR) 0.547, confidence interval (CI) 0.455-0.659). All criteria for gastric lavage were fulfilled in 60 lavaged cases (5.5%), and the fraction did not improve significantly over the period (OR 1.717, CI 0.791-3.724). No individual criterion for lavage showed consistent improvement over the period.
CONCLUSION: Gastric lavage is still widely used in Denmark, mostly on questionable grounds where the procedure is unlikely to be beneficial. Recommendations for gastrointestinal decontamination may need to be promoted more actively, and clinicians should be encouraged to seek toxicological advice before performing gastric lavage.
PMID
22292974 Clin Toxicol (Phila). 2012 Feb;50(2):129-35. doi: 10.31･･･
著者: Meg A Rosenblatt, Mark Abel, Gregory W Fischer, Chad J Itzkovich, James B Eisenkraft
雑誌名: Anesthesiology. 2006 Jul;105(1):217-8. doi: 10.1097/00000542-200607000-00033.
Abstract/Text
PMID
16810015 Anesthesiology. 2006 Jul;105(1):217-8. doi: 10.1097/000･･･
