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著者: Ian G McKeith, Tanis J Ferman, Alan J Thomas, Frédéric Blanc, Bradley F Boeve, Hiroshige Fujishiro, Kejal Kantarci, Cristina Muscio, John T O'Brien, Ronald B Postuma, Dag Aarsland, Clive Ballard, Laura Bonanni, Paul Donaghy, Murat Emre, James E Galvin, Douglas Galasko, Jennifer G Goldman, Stephen N Gomperts, Lawrence S Honig, Manabu Ikeda, James B Leverenz, Simon J G Lewis, Karen S Marder, Mario Masellis, David P Salmon, John Paul Taylor, Debby W Tsuang, Zuzana Walker, Pietro Tiraboschi, prodromal DLB Diagnostic Study Group
雑誌名: Neurology. 2020 Apr 28;94(17):743-755. doi: 10.1212/WNL.0000000000009323. Epub 2020 Apr 2.
Abstract/Text
The prodromal phase of dementia with Lewy bodies (DLB) includes (1) mild cognitive impairment (MCI), (2) delirium-onset, and (3) psychiatric-onset presentations. The purpose of our review is to determine whether there is sufficient information yet available to justify development of diagnostic criteria for each of these. Our goal is to achieve evidence-based recommendations for the recognition of DLB at a predementia, symptomatic stage. We propose operationalized diagnostic criteria for probable and possible mild cognitive impairment with Lewy bodies, which are intended for use in research settings pending validation for use in clinical practice. They are compatible with current criteria for other prodromal neurodegenerative disorders including Alzheimer and Parkinson disease. Although there is still insufficient evidence to propose formal criteria for delirium-onset and psychiatric-onset presentations of DLB, we feel that it is important to characterize them, raising the index of diagnostic suspicion and prioritizing them for further investigation.
Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.
PMID 32241955 Neurology. 2020 Apr 28;94(17):743-755. doi: 10.1212/WNL.0000000000009323. Epub 2020 Apr 2.
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