| |
著者: Marie Bourgault, Philippe Grimbert, Catherine Verret, Jacques Pourrat, Michel Herody, Jean Michel Halimi, Alexandre Karras, Zahir Amoura, Noémie Jourde-Chiche, Hassan Izzedine, Hélène François, Jean-Jacques Boffa, Aurélie Hummel, Pauline Bernadet-Monrozies, Denis Fouque, Florence Canouï-Poitrine, Philippe Lang, Eric Daugas, Vincent Audard
雑誌名: Clin J Am Soc Nephrol. 2013 Mar;8(3):392-8. doi: 10.2215/CJN.05570612. Epub 2012 Nov 30.
Abstract/Text
BACKGROUND AND OBJECTIVES: Renal infarction is an arterial vascular event that may cause irreversible damage to kidney tissues. This study describes the clinical characteristics of patients with renal infarction according to underlying mechanism of vascular injury.
DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This study retrospectively identified 94 patients with renal infarction diagnosed between 1989 and 2011 with the aim of highlighting potential correlations between demographic, clinical, and biologic characteristics and the etiology of renal infarction. Four groups were identified: renal infarction of cardiac origin (cardiac group, n=23), renal infarction associated with renal artery injury (renal injury group, n=29), renal infarction associated with hypercoagulability disorders (hypercoagulable group, n=15), and apparently idiopathic renal infarction (idiopathic group, n=27).
RESULTS: Clinical symptoms included abdominal and/or flank pain in 96.8% of cases; 46 patients had uncontrolled hypertension at diagnosis. Laboratory findings included increase of lactate dehydrogenase level (90.5%), increase in C-reactive protein level (77.6%), and renal impairment (40.4%). Compared with renal injury group patients, this study found that cardiac group patients were older (relative risk for 1 year increase=1.21, P=0.001) and displayed a lower diastolic BP (relative risk per 1 mmHg=0.94, P=0.05). Patients in the hypercoagulable group had a significantly lower diastolic BP (relative risk=0.86, P=0.005). Patients in the idiopathic group were older (relative risk=1.13, P=0.01) and less frequently men (relative risk=0.11, P=0.02). Seven patients required hemodialysis at the first evaluation, and zero patients died during the first 30 days.
CONCLUSIONS: This study suggests that the clinical and biologic characteristics of patients can provide valuable information about the causal mechanism involved in renal infarction occurrence.
PMID 23204242 Clin J Am Soc Nephrol. 2013 Mar;8(3):392-8. doi: 10.2215/CJN.05570612. Epub 2012 Nov 30.
|
